Award
NIH Reporter #5R01AG079241-05
Longitudinal validation of retinal biomarkers against cerebral imaging in preclinical Alzheimer's disease
Recipient
University of Rhode Island, Kingston, RI, United States
Award Amount
$2,002,901.00
Ceiling
$2,002,901.00
Awarded
May 28, 2026
Identifier
5R01AG079241-05
This award funds a study to validate retinal biomarkers against cerebral imaging for early detection of Alzheimer's disease, aiming to improve screening and early intervention.
Description
Alzheimer’s disease (AD) is a neurodegenerative disorder leading to cognitive and functional loss. The study aims to identify retinal biomarkers of preclinical AD, validate them against brain imaging biomarkers, and assess their predictive value for disease progression. It leverages the ARIAS infrastructure, adding MRI, PET, and plasma biomarkers, with follow-up over 3 years.