Award
NIH Reporter #1R21HL184214-01
Developing breath biomarkers of S. aureus cystic fibrosis lung infections through the secondary analysis of IMPACT-Breath clinical study data
Recipient
Arizona State University - Tempe Campus, Scottsdale, AZ
Award Amount
$233,854.00
Ceiling
$233,854.00
Awarded
May 25, 2026
Identifier
1R21HL184214-01
This award funds research to develop non-invasive breath tests for detecting Staphylococcus aureus lung infections in cystic fibrosis patients, using secondary analysis of clinical study data to identify specific biomarkers.
Description
The project aims to identify breath biomarkers of Staphylococcus aureus, the most common cause of cystic fibrosis lung infections, to enable non-invasive and rapid detection of these infections in patients who cannot produce sputum. The project involves developing sensitive and specific breath tests, analyzing breath volatilomics data and clinical metadata, building classification models, identifying biomarkers to differentiate infection types, and providing preliminary data for a prospective clinical study.