Award
NIH Reporter #1R21MH144609-01
Mechanistic Dissection of SRRM2-Mediated RNA Splicing and Subnuclear RNA Organization in Human Neurons
Recipient
Icahn School of Medicine at Mount Sinai
Award Amount
$462,000.00
Ceiling
$462,000.00
Awarded
August 18, 2026
Identifier
1R21MH144609-01
NIH awarded $462,000 to Icahn School of Medicine at Mount Sinai for research on SRRM2's role in RNA splicing and localization in human neurons, focusing on schizophrenia.
Description
This project aims to develop a spatial omics platform to investigate how the schizophrenia risk gene SRRM2 regulates RNA splicing and localization in human neurons. Using advanced spatial transcriptomics and gene editing techniques, the project will explore SRRM2's role in neuronal function and its implications for psychiatric disorders.