Award
National Institute of Neurological Disorders and Stroke 1F31NS147424-01
Identifying astroglia-mediated mechanisms contributing to neuronal vulnerability in Spinocerebellar Ataxia Type 1
Recipient
Yale University
Award Amount
$50,114.00
Ceiling
$50,114.00
Awarded
March 24, 2026
Identifier
1F31NS147424-01
Research project funded to study astroglia's role in Spinocerebellar Ataxia Type 1 using a mouse model to understand disease mechanisms affecting Purkinje cells.
Description
The project aims to explore the role of astroglia in disease progression by creating an astroglia-specific SCA1 mouse model (AG-SCA1) to study how mutant ataxin-1 impacts Purkinje cell health and function. The research will involve behavioral, histopathological, electrophysiological, and molecular analyses, including single-nucleus RNA sequencing, to understand non-cell-autonomous mechanisms contributing to neurodegeneration.