Award
National Heart, Lung, and Blood Institute 5UH3HL161338-05
1/2 percutaneous intervention versus observational trial of arterial ductus in lower gestational age infants (PIVOTAL)
Recipient
Research Institute Nationwide Children's Hospital, Columbus, OH, United States
Award Amount
$418,217.00
Ceiling
$418,217.00
Awarded
March 04, 2026
Identifier
5UH3HL161338-05
A NIH-funded research project evaluating the effectiveness of percutaneous catheter-based closure of patent ductus arteriosus in preterm infants to improve neonatal outcomes.
Description
This project is a multicenter randomized trial to determine whether percutaneous closure of hemodynamically significant patent ductus arteriosus (HSPDA) using a novel FDA-approved duct occluder (ADO-II AS) improves cardiopulmonary and neurodevelopmental outcomes in preterm infants compared to supportive, non-invasive therapy.