Award
NIH Reporter #1R21AI203526-01
Estimating the causal effect of early peanut introduction on the risk of food protein enterocolitis syndrome (FPIES)
Recipient
Northwestern University
Award Amount
$250,642.00
Ceiling
$250,642.00
Awarded
September 01, 2026
Identifier
1R21AI203526-01
This award funds a research project to study the causal effect of early peanut introduction on the risk of developing Food Protein-Induced Enterocolitis Syndrome (FPIES) using data from a large clinical trial. The goal is to inform guidelines and clinical practices regarding peanut allergy prevention and FPIES risk.
Description
The study aims to estimate the impact of the 2017 Addendum Guidelines for the Prevention of Peanut Allergy (PPA) on the diagnosis of Food Protein-Induced Enterocolitis Syndrome (FPIES). It leverages data from a large cluster-randomized clinical trial (iREACH) involving electronic health records of 18,480 infants across 30 pediatric practices. The research will model the incidence of peanut FPIES as a function of early peanut introduction and assess the effect of the intervention on allergic reactions and FPIES incidence.