Award
National Institute of General Medical Sciences 5P20GM121312-09
Neurology of Effortful Neutralization of Threat in Obsessive-Compulsive Disorder
Recipient
LAUREATE INSTITUTE FOR BRAIN RESEARCH
Award Amount
$237,849.00
Ceiling
$237,849.00
Awarded
July 07, 2026
Identifier
5P20GM121312-09
The award funds research on the neural and behavioral mechanisms of compulsions in OCD, focusing on effortful threat neutralization using a novel fMRI task to identify specific neural activity and behavior patterns in OCD patients compared to healthy controls.
Description
This project investigates behavioral and neural biomarkers related to effortful neutralization of threat (ENT) in Obsessive-Compulsive Disorder (OCD) using a novel fMRI paradigm called the Tap-To-Safety (TTS) task. The study aims to identify OCD-specific patterns of behavior and neural activity associated with ENT to improve understanding and treatment of OCD.