Award
National Cancer Institute 5R01CA272946-04
Re-engineering differential regulation of ferroptosis in melanoma microenvironment
Recipient
University of Pittsburgh at Pittsburgh
Award Amount
$642,352.00
Ceiling
$642,352.00
Awarded
June 09, 2026
Identifier
5R01CA272946-04
The award supports research to understand and manipulate ferroptosis regulation in melanoma and immune cells within the tumor microenvironment to develop targeted therapies, addressing challenges in melanoma treatment including immune tolerance and resistance.
Description
This project aims to uncover mechanisms of ferroptosis regulation in polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) and melanoma cells using lipidomics mass spectrometry and single-cell lipidomics imaging. The goal is to optimize a therapeutic approach to promote ferroptosis in malignant cells while protecting and enhancing anti-tumor immunity, employing nano-delivery systems based on graphene quantum nanodots and carbon nanotubes.