Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK137945-03
Effect of Maternal Exercise in Women with Obesity on Offspring Mesenchymal Stem Cell Metabolism
Recipient
East Carolina University, Greenville, NC, United States
Award Amount
$552,661.00
Ceiling
$552,661.00
Awarded
December 15, 2025
Identifier
5R01DK137945-03
The study investigates the impact of maternal exercise during pregnancy in women with obesity on the metabolism of offspring mesenchymal stem cells, aiming to understand mechanisms and associations with infant health outcomes.
Description
This project explores how maternal exercise affects offspring cellular metabolism using MSCs derived from infant umbilical cords, with a focus on gene and epigenetic signatures, and correlates these with whole-body metabolic outcomes over the first year of life.