Award
NIH Reporter #4R01NS117509-02
White Matter Restoration in Vascular Cognitive Impairment and dementia
Recipient
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
Award Amount
$561,842.00
Ceiling
$561,842.00
Awarded
July 09, 2024
Identifier
4R01NS117509-02
This NIH-funded project aims to develop new therapeutic interventions to repair white matter injury and address cognitive dysfunction and dementia by converting astrocytes into myelin-producing oligodendrocytes in a vascular cognitive impairment model.
Description
The project focuses on developing therapeutic strategies for white matter injury and cognitive impairment related to vascular issues. The project involves innovative reprogramming of astrocytes into oligodendrocytes. The study aims to convert activated astrocytes into oligodendrocytes in situ in a model of chronic common carotid artery hypoperfusion to restore white matter structure and function and enhance cognitive function.