Award
National Institute of Diabetes and Digestive and Kidney Diseases 5K08DK135931-04
Understanding the physiology and pathophysiology of kidney-derived vasopressin
Recipient
Vanderbilt University Medical Center
Award Amount
$158,436.00
Ceiling
$158,436.00
Awarded
March 25, 2026
Identifier
5K08DK135931-04
NIH awarded a research grant to Vanderbilt University Medical Center to study kidney-derived vasopressin's role in water balance and kidney diseases using transgenic mouse models.
Description
This NIH grant project aims to understand the role of kidney-derived vasopressin in health and disease using cell and transgenic mouse models with targeted deletion of vasopressin in the kidney. The research focuses on how kidney-derived vasopressin influences water balance and its involvement in cyst growth and polycystic kidney disease progression, potentially leading to new therapeutic targets for chronic kidney disease and PKD.