Award
National Institute of Diabetes and Digestive and Kidney Diseases RFA-DK-22-022
Loss of insulin signaling across functional pancreas compartments as a major pathogenic mechanism underlying diabetic exocrine pancreatopathy
Recipient
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Award Amount
$662,173.00
Ceiling
$662,173.00
Awarded
December 18, 2025
Identifier
RFA-DK-22-022
Research project funded by NIDDK to study the role of insulin signaling in pancreatic compartments and its link to diabetic exocrine pancreatopathy, involving in vivo mouse studies and human tissue analysis.
Description
The project aims to generate mechanistic insights into how beta cells influence surrounding tissues in the pancreas, focusing on insulin signaling and its impact on exocrine tissue, vasculature, and neural coordination. The project involves in vivo studies in mice and analysis of human pancreas slices. The research is relevant to understanding diabetes pathogenesis and developing therapeutic strategies.