Award
National Institute of General Medical Sciences 5R35GM130302-07
Centromere identity, strength, and regulation
Recipient
University of Pennsylvania, Philadelphia, PA, United States
Award Amount
$632,821.00
Ceiling
$632,821.00
Awarded
December 16, 2025
Identifier
5R35GM130302-07
This award funds research on centromere biology and chromosome segregation using advanced imaging techniques to understand chromosome inheritance and prevent genetic disorders.
Description
The project focuses on understanding the molecular basis of centromere identity, the epigenetic pathways that propagate centromeric chromatin, and the quality control pathways ensuring proper chromosome segregation during cell division. It involves advanced structural biology techniques including cryo-electron tomography to visualize the centromere in its natural chromosomal context during mitosis and throughout the cell cycle. The research aims to provide vital insights into chromosome inheritance and the prevention of genetic catastrophes such as aneuploidy.