National Cancer Institute 1R01CA303285-01A1

Sequence-specific inhibition of c-Myc in vivo by next-generation nucleic acid analogs

Award for research on sequence-specific DNA targeting molecules to inhibit c-Myc gene in cancer therapy, involving preclinical testing in cell lines and mouse models.

Description

This project involves developing sequence-specific DNA targeting molecules (gPNA) conjugated with nuclear localization sequences and tumor-targeting peptides for cancer therapy, specifically targeting the c-Myc gene in lymphoma and other cancers. The project includes preclinical testing in cell lines and mouse models, with a focus on improving efficacy and reducing animal use.

View original record