Award
National Institute of General Medical Sciences 5R35GM126966-09
Mechanisms of Circadian Clock Control of mRNA Translation
Recipient
Texas A&M University, College Station, TX, United States
Award Amount
$757,952.00
Ceiling
$757,952.00
Awarded
April 27, 2026
Identifier
5R35GM126966-09
This award supports research on the circadian clock's role in controlling mRNA translation and protein synthesis, focusing on mechanisms that affect protein diversity and folding, using Neurospora crassa as a model organism.
Description
The project investigates how the circadian clock influences protein synthesis and folding using the model organism Neurospora crassa. It aims to understand clock control of translation fidelity and protein diversity, including rhythmic stop codon readthrough and regulation of tRNA synthetases, with implications for treating clock-associated diseases.