Award
NIH Reporter #1K99DK146108-01A1
Interrogating selection of autoreactive T cells using isogenic human thymic organoids
Recipient
Not specified
Awarded
August 31, 2026
Identifier
1K99DK146108-01A1
Research project focused on understanding the selection and development of autoreactive T cells using human thymic organoids and genetic engineering techniques.
Description
This project aims to investigate how pre-proinsulin-reactive T cell receptor affinity influences autoreactive T cell development and their cytolytic destruction of stem cell-derived β-cells, using human isogenic systems and genetic engineering of thymic cells and T cell progenitors.