NIH Reporter #5K08HL172012-03

Characterization of PHF7 function in mediating cardiac reprogramming

This NIH K08 grant supports Dr. Glynnis Garry's research on PHF7's role in cardiac reprogramming to promote heart regeneration after myocardial infarction, aiming to develop novel therapies for ischemic heart disease and heart failure.

Description

The goal of this K08 application is to provide a rigorous 5-year scientific and career development training plan that will facilitate the transition of Dr. Glynnis Garry from a post-doctoral fellow to a fully independent investigator as a cardiovascular physician-scientist. The research focuses on investigating direct cardiac reprogramming to promote heart regeneration following myocardial infarction, with a focus on the histone reader PHF7 as a potent activator of adult reprogramming. Preliminary work demonstrated PHF7's ability to activate reprogramming in adult human and mouse fibroblasts and improve cardiac function post-myocardial infarction. The proposed research aims to define the role of PHF7 in adult human reprogramming, assess its ability to improve cardiac function, and elucidate mechanisms by which PHF7 induces reprogramming and functional improvements.

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