Award
National Institute of General Medical Sciences 5R35GM131914-07
Planar cell polarity mechanisms and systems architecture
Recipient
Stanford University
Award Amount
$974,917.00
Ceiling
$974,917.00
Awarded
August 07, 2025
Identifier
5R35GM131914-07
NIH grant awarded to Stanford University to study planar cell polarity mechanisms using genetic tools and imaging techniques, aiming to understand cellular polarization and develop therapeutic interventions.
Description
This NIH grant project aims to dissect the molecular and cellular mechanisms of planar cell polarity (PCP) signaling using Drosophila models, combining genetic tools, single molecule imaging, and biochemistry to understand feedback mechanisms, molecular asymmetry, and clustering roles in polarization. The project seeks to develop novel genetic tools, analyze feedback and clustering in PCP signaling, deliver insights into molecular logic and mechanisms, and lay groundwork for therapeutic interventions for PCP-related pathologies.