Award
NIH Reporter #1R01CA305930-01A1
Role of P4HA2 in metastatic dormancy
Recipient
ICHAN SCHOOL OF MEDICINE AT MOUNT SINAI, NY, USA
Award Amount
$827,111.00
Ceiling
$827,111.00
Awarded
July 21, 2026
Identifier
1R01CA305930-01A1
Research project funded by the National Cancer Institute to study the role of P4HA2 enzyme in tumor dormancy and metastasis, using advanced imaging and AI methods to identify new anti-metastatic targets.
Description
This project investigates the mechanisms of collagen modifications in the context of tumor dormancy. Outcomes will reveal how disseminated tumor cells regulate proline hydroxylation of collagen and the crosstalk with autophagy and mitochondria function. Findings will be applied towards finding novel anti-metastatic targets.