Award
National Institute of General Medical Sciences 5R16GM149512-04
Dermal-Epidermal Junction Disruptors: Toxicodynamic Mechanisms
Recipient
St. John's University, Queens, NY, United States
Award Amount
$164,000.00
Ceiling
$164,000.00
Awarded
June 19, 2026
Identifier
5R16GM149512-04
NIH grant awarded to St. John's University to study mechanisms of skin blistering caused by dermal-epidermal junction disruptors, aiming to identify therapeutic targets.
Description
Research project investigating the toxicodynamic mechanisms of dermal-epidermal junction disruption caused by chemical agents, focusing on mast cell-derived mediators, neutrophil-derived mediators, and keratinocyte-specific collagens using mouse models and human 3D skin cultures.