# NIH Reporter #1R01EY038065-01A1

All-optical interrogation of the biological mechanisms of learning

**Recipient:** University of California Berkeley

**Award Amount:** $740,790.00
**Ceiling:** $740,790.00

**Awarded:** September 10, 2026

**Identifier:** 1R01EY038065-01A1

This award funds the development of new optical technologies to measure and track synaptic weights in the brain during learning, enhancing understanding of neural mechanisms of learning and memory.

### Description

The project aims to establish and leverage a new paradigm to optically measure and track synaptic weights in the brains of awake animals as they learn and store information. It involves developing a system combining optogenetic photostimulation and a genetically encoded voltage indicator for subthreshold voltage imaging to map and monitor synaptic weights across thousands of candidate synaptic connections in the visual cortex during learning and deprivation-induced plasticity.

[View original record](https://reporter.nih.gov/search/0C83gI3MXki4-tEhFD4UKQ/project-details/11465395)