Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases PA-20-185
Engineered cells as agents of arthritis therapy governed by artificial signaling
Recipient
Vanderbilt University, Nashville, TN, United States
Award Amount
$394,830.00
Ceiling
$394,830.00
Awarded
July 31, 2025
Identifier
PA-20-185
Development of engineered cells with synthetic receptors to detect cartilage damage and deliver targeted gene therapy for osteoarthritis treatment.
Description
This project aims to develop synthetic receptor-controlled, joint-resident cells that can detect cartilage damage and deliver therapeutic transgenes to promote repair and reduce inflammation in osteoarthritis. The approach involves engineering cells with synthetic receptors to respond to collagen II exposure, enabling targeted therapy in arthritic joints.