Award
National Institute on Alcohol Abuse and Alcoholism 5R01AA031805-02
Mechanistic characterization of JNK2α variants in alcohol-caused heart failure
Recipient
Ohio State University
Award Amount
$595,178.00
Ceiling
$595,178.00
Awarded
June 19, 2026
Identifier
5R01AA031805-02
Research project funded by NIH to study molecular mechanisms of alcohol-related heart failure, focusing on JNK2α variants and their role in cardiac dysfunction and potential therapeutic targets.
Description
This project aims to define how JNK2α variants contribute to alcoholic cardiomyopathy (ACM) development via regulation of SERCA2 pump activity and transcription. Outcomes will reveal mechanisms of ACM onset and explore JNK2α variants as therapeutic targets.