Award
National Institute of General Medical Sciences 5R35GM142884-05
DEFINING REGULATORY ROLES FOR HISTONE H3 METHYLATION IN DEVELOPMENT
Recipient
University of Colorado, Boulder, CO, United States
Award Amount
$385,000.00
Ceiling
$385,000.00
Awarded
May 06, 2025
Identifier
5R35GM142884-05
The award supports research to define the regulatory roles of histone H3 methylation at residues H3K9 and H3K36 in stem cell differentiation and development, using innovative K-to-M mutant histones to study epigenetic mechanisms in vitro and in vivo.
Description
This project aims to elucidate the roles of histone methylation in stem cell differentiation and development, with potential implications for regenerative medicine and understanding developmental biology. The research will define the regulatory role of methylation at two key histone residues, H3K9 and H3K36, in directing differentiation, both in vitro and in vivo. The approach uses lysine-to-methionine (K-to-M) mutations on histone H3 to study the function of methylation on H3K9 and H3K36 during developmental transitions.