Award
National Institute of Neurological Disorders and Stroke 5F31NS141228-02
Investigating the function of a ciliary protein in neural development
Recipient
University of Washington
Award Amount
$50,114.00
Ceiling
$50,114.00
Awarded
June 02, 2026
Identifier
5F31NS141228-02
The award supports research investigating the role of a ciliary protein in neural development, using advanced genetic and biochemical methods in C. elegans to understand synapse formation and its implications for neurological disorders.
Description
This project aims to uncover novel molecular mechanisms involved in synapse formation, focusing on a ciliary protein with a potential non-ciliary function in neural development. The research will utilize genetics, super-resolution microscopy, and proteomics in C. elegans. The work will use in-vivo experimental techniques such as CRISPR editing and engineering, genetics, and biochemistry to investigate the function of a ciliary protein in GABAergic neurons and its relationship with RPM-1 ubiquitin ligase, examine its role in ciliated neurons using C. elegans, and explore its influence on ciliated neuron development through genetics and neuron-specific transgenic approaches.