Award
National Institute of Allergy and Infectious Diseases 5R01AI158596-04
Understanding A Molecular Cascade That Drives Neutrophil Mediated Pathology In Arthritis
Recipient
University of Virginia
Award Amount
$489,918.00
Ceiling
$489,918.00
Awarded
January 29, 2026
Identifier
5R01AI158596-04
NIH-funded research grant awarded to University of Virginia to study the molecular mechanisms by which ELMO1 protein drives neutrophil-mediated pathology in rheumatoid arthritis, aiming to identify new therapeutic targets.
Description
Research project focusing on the role of the engulfment and cell motility protein-1 (ELMO1) in disease development in mouse models of rheumatoid arthritis by facilitating recruitment of neutrophils into the joints, contributing to inflammation and bone degradation. The research aims to delineate the mechanisms by which ELMO1 regulates neutrophil recruitment into joints, potentially leading to new therapeutic targets.