Award
National Institute of Allergy and Infectious Diseases 7R01AI175831-04
Targeting host lipid metabolism to limit tissue damage in necrotizing fasciitis
Recipient
University of Southern California
Award Amount
$644,923.00
Ceiling
$644,923.00
Awarded
March 31, 2026
Identifier
7R01AI175831-04
Research project funded by NIAID to study lipid metabolism's role in protecting against tissue damage in necrotizing fasciitis, aiming to find new therapeutic targets.
Description
This project investigates how lipid metabolism influences tissue damage caused by CDC toxins and GAS infections, aiming to identify new therapeutic targets. Necrotizing Fasciitis (NF) is a rapidly progressing bacterial infection with severe tissue necrosis. The project focuses on the CH25H-LXR metabolic axis, skin cell types involved in protection, and modulation of lipid homeostasis in disease pathogenesis.