Award
National Cancer Institute 1R37CA315608-01
Innate immune memory for glioma immunotherapy
Recipient
Duke University
Award Amount
$509,581.00
Ceiling
$509,581.00
Awarded
July 28, 2026
Identifier
1R37CA315608-01
This award funds research on virotherapy for glioma immunotherapy, focusing on the role of bone marrow progenitors in tumor inflammation and immune response, aiming to improve treatment efficacy for glioblastoma patients.
Description
Clinical trials of intratumor immunotherapies that stimulate antitumor T cell function, such as virotherapy, have shown encouraging early results in lethal WHO grade IV gliomas but are not effective in most patients to date. The research aims to define effective virotherapy in glioma patients, determine the role of bone marrow progenitors in mediating glioma inflammation and responsiveness, and develop strategies to engage antitumor functions of bone marrow progenitors.