Award
National Cancer Institute 1R37CA297078-01A1
Targeting non-genetic and genetic mechanisms to overcome drug resistance in acute myeloid leukemia
Recipient
Emory University, Atlanta, GA
Award Amount
$639,859.00
Ceiling
$639,859.00
Awarded
April 28, 2026
Identifier
1R37CA297078-01A1
This NIH grant project focuses on understanding and overcoming drug resistance in acute myeloid leukemia by studying molecular mechanisms and testing targeted therapies to prevent relapse.
Description
Most leukemia patients eventually succumb to their disease due to resistance to both conventional chemotherapy and innovative targeted therapy. To understand the molecular basis of resistance, phenotypic data will be integrated with genotypic abnormalities identified through unbiased approaches. The project aims to identify effective treatments for drug-resistant leukemia models using dynamic BH3 profiling to measure cell death readiness in response to drug therapies.