Award
National Institute of Allergy and Infectious Diseases 5R21AI182709-02
Structural, functional, and microbiological exploration toward synergistic dual aminoglycoside combinations
Recipient
University of Illinois at Chicago, Chicago, IL, United States
Award Amount
$197,436.00
Ceiling
$197,436.00
Awarded
March 30, 2026
Identifier
5R21AI182709-02
The award funds research on synergistic dual aminoglycoside antibiotic combinations to combat multidrug-resistant Gram-negative bacteria by understanding their mechanisms and developing improved drugs.
Description
This project explores dual-aminoglycoside combinations that bind separate sites on the bacterial ribosome, which have shown synergistic bactericidal activity against multidrug-resistant Gram-negative bacteria. The research aims to elucidate the mechanisms of synergy, identify optimal combinations, and develop structural insights to guide next-generation drug development.