Award
National Institute of Allergy and Infectious Diseases 5R01AI127372-10
Human ISG15 and USP18 Deficiencies Underlying Type I Interferonopathies
Recipient
Columbia University Health Sciences
Award Amount
$465,050.00
Ceiling
$465,050.00
Awarded
May 27, 2026
Identifier
5R01AI127372-10
NIH awarded a research grant to Columbia University Health Sciences to study the regulation of Type I Interferon response by ISG15 and USP18 deficiencies, which are linked to interferonopathies and immune diseases.
Description
This project aims to delineate the regulation of the Type I Interferon (IFN-I) response by ISG15 and USP18, which are involved in immune response regulation and are linked to severe neurologic, autoinflammatory, and autoimmune diseases known as interferonopathies. The study will investigate these deficiencies in vitro, ex vivo, and in vivo to understand their role in IFN-I pathway regulation and resistance to viral infections.