Award
National Heart, Lung, and Blood Institute 4R00HL175037-03
Unraveling Fatty Acid-driven Mechanisms of Platelet Hyper-Activation in Obesity
Recipient
Research Institute Nationwide Children's Hospital, Columbus, OH, United States
Award Amount
$249,000.00
Ceiling
$249,000.00
Awarded
July 27, 2026
Identifier
4R00HL175037-03
A NIH grant awarded to Research Institute Nationwide Children's Hospital to study how dietary saturated fatty acids affect platelet function and contribute to obesity-related cardiovascular complications.
Description
This research grant aims to uncover the mechanisms by which dietary saturated fatty acids (SFAs) are integrated into platelet membranes and how this influences platelet function, particularly in the context of obesity-related platelet hyperreactivity and cardiovascular risks. The project involves in vitro and in vivo studies focusing on lipid raft composition and receptor signaling in platelets.