Award
NIH Reporter #3R01CA272898-05S1
The Role of Secondary Bile Acids in Gastro-Esophageal Neoplasia
Recipient
Columbia University Health Sciences
Award Amount
$245,000.00
Ceiling
$245,000.00
Awarded
September 17, 2026
Identifier
3R01CA272898-05S1
Research project funded by the National Cancer Institute to study the role of secondary bile acids in gastroesophageal cancer development and prevention, using advanced biological models and techniques.
Description
This project investigates how secondary bile acids influence stem cell fate and microenvironment at the gastroesophageal junction (GEJ), aiming to develop targeted therapies to prevent cancer. The research uses mouse models, organoids, patient studies, and advanced techniques like single-cell RNA sequencing and CyTOF to understand the effects of bile acids produced by gut bacteria on GEJ stem cells and cancer development. The goal is to identify novel therapeutic targets and strategies, including probiotic therapy, to prevent gastroesophageal cancer.