Award
National Institute of General Medical Sciences 5R35GM156397-02
UBIQUITIN-PROTEASOME PATHWAY in HUMAN DISEASE
Recipient
University of Connecticut School of Medicine
Award Amount
$471,611.00
Ceiling
$471,611.00
Awarded
January 15, 2026
Identifier
5R35GM156397-02
NIH grant awarded to University of Connecticut School of Medicine to study the Ubiquitin-Proteasome Pathway, focusing on USP7 enzyme and its mutants related to human diseases including cancer and neurodevelopmental disorders.
Description
This MIRA proposal aims to extend our successful Ubiquitin-Proteasome Pathway research program with a vision to structurally and functionally characterize critical ubiquitinating and de-ubiquitinating enzymes implicated in human cancers and neurodevelopmental diseases. The research will focus on deubiquitinating enzyme USP7 and its hyperactive mutants identified among mutations causing Hao-Fountain syndrome, providing mechanistic insights and guiding future therapeutic strategies.