Award
NIH Reporter #5U01CA282114-04
Spatial functional genomics to identify regulators of the tumor microenvironment and cancer immunity
Recipient
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY, USA
Award Amount
$1,015,344.00
Ceiling
$1,015,344.00
Awarded
August 31, 2026
Identifier
5U01CA282114-04
Award for research using spatial functional genomics to study tumor microenvironment and cancer immunity across multiple cancer types, aiming to develop personalized therapies.
Description
The project aims to identify genes controlling tumor composition, growth, and resistance to immunotherapy, using a spatial functional genomics platform called Perturb-map. The study will analyze critical tumor processes in models of lung, ovarian, pancreatic, and oral cancers to generate insights into tumor behavior and resistance mechanisms, ultimately guiding personalized treatment strategies.