Award
National Institute on Aging 1RF1NS136861-01
Investigating the Role and the therapeutic potential of Perlecan in experimental vascular dementia
Recipient
Tulane University of Louisiana
Award Amount
$2,573,724.00
Ceiling
$2,573,724.00
Awarded
June 12, 2024
Identifier
1RF1NS136861-01
A research project funded by the National Institute on Aging to study the role of perlecan in vascular dementia and evaluate the therapeutic potential of its LG3 fragment in mouse models.
Description
This project aims to understand the role of perlecan and its LG3 fragment in vascular dementia using mouse models, including eNOS-deficient and hypoxia-exposed mice. The research explores the therapeutic potential of LG3 replacement therapy to improve blood-brain barrier integrity and cognitive function in vascular dementia.