Award
National Institute of Mental Health 5R01MH108509-10
The RAW Brain - The Effect of Rumination, Anxiety and Worry on Aging and Dementia Risk
Recipient
University of Pittsburgh at Pittsburgh
Award Amount
$1,514,011.00
Ceiling
$1,514,011.00
Awarded
July 09, 2026
Identifier
5R01MH108509-10
Research project studying the impact of rumination, anxiety, and worry on aging and dementia risk, identifying neurobiological markers and pathways.
Description
The project investigates how rumination, anxiety, and worry (RAW) influence brain and body aging, with a focus on dementia risk. It aims to identify neurobiological pathways and markers, including hippocampal atrophy, cerebrovascular burden, plasma amyloid, and peripheral stress markers. The study will follow a cohort of older adults, including 150 existing and 150 new participants, over multiple years, utilizing clinical, neuropsychological, and multimodal imaging measures.