Award
NIH Reporter #1R21AI190535-01A1
Overcoming innate drug efflux systems to expand anthelmintic vulnerability
Recipient
Iowa State University, Ames, IA
Award Amount
$453,063.00
Ceiling
$453,063.00
Awarded
February 13, 2026
Identifier
1R21AI190535-01A1
This award funds research to study drug efflux transporters in nematode parasites to improve the effectiveness of antiparasitic drugs by inhibiting these transporters.
Description
The project aims to investigate ATP-binding cassette transporters that remove antiparasitic drugs from nematode cells. Inhibition of P-glycoproteins will restore efficacy for existing anthelmintic drugs. The research is relevant to protecting the public from parasitic diseases.