Award
NIH Reporter #5U24AG057437-09
Alzheimer's Clinical Trials Consortium (ACTC)
Recipient
University of Southern California, Los Angeles, CA
Award Amount
$30,442,169.00
Ceiling
$30,442,169.00
Awarded
August 19, 2026
Identifier
5U24AG057437-09
The award funds the Alzheimer's Clinical Trials Consortium to conduct and expand NIH-supported clinical trials in Alzheimer's disease, focusing on innovative trial designs, collaboration, and advanced outcomes.
Description
This is a multi-Principal Investigator (PI) application renewing the U24 Cooperative Agreement to sustain and expand the NIA’s Alzheimer Clinical Trial Consortium (ACTC). The ACTC conducts academic clinical trials across the continuum of Alzheimer’s disease (AD). The consortium leverages expertise from USC, Harvard, Mayo Clinic, and 35 expert AD trial sites. The goal is to develop and conduct high-quality NIH-supported clinical trials in AD and related dementias, utilizing streamlined contracting, centralized IRB, advanced informatics, and innovative trial designs. The project aims to support novel cognitive, imaging, and biomarker outcomes, incorporate exploratory measures like Tau PET imaging, and facilitate rapid assessment of efficacy signals. It emphasizes collaboration across multiple institutions, training for young investigators, and strategic partnerships to conduct large-scale and investigator-initiated studies.