Award
National Heart, Lung, and Blood Institute 5R01HL176770-02
Regulation of disease progression by ER stress
Recipient
University of Alabama at Birmingham
Award Amount
$650,456.00
Ceiling
$650,456.00
Awarded
June 26, 2026
Identifier
5R01HL176770-02
NIH grant awarded to University of Alabama at Birmingham to study ER stress in macrophage metabolic reprogramming and fibrosis progression related to asbestos-induced disease.
Description
This project aims to investigate the role of ER stress and UPR in macrophage metabolic reprogramming and fibrosis progression, with potential therapeutic implications. There is no current curative therapy for asbestos-induced fibrosis. Recruited monocyte-derived macrophages (MDMs) play a critical role in the pathogenesis of asbestos-induced disease progression. The activation of MDMs depends on their metabolic profile, with metabolic reprogramming being a key feature.