Award
Eunice Kennedy Shriver National Institute of Child Health and Human Development 5R21HD118147-02
Neural Crest Regulation of Embryonic Calcium Uptake
Recipient
Cincinnati Children's Hospital Medical Center
Award Amount
$240,750.00
Ceiling
$240,750.00
Awarded
February 26, 2026
Identifier
5R21HD118147-02
Research grant studying how Sox10 gene affects calcium uptake in embryos for bone development, using zebrafish models to explore cellular and molecular mechanisms.
Description
This project investigates the role of the transcription factor Sox10 in regulating embryonic calcium uptake necessary for bone mineralization, using a zebrafish model. It aims to identify the Sox10+ crest-derived lineage interacting with an endocrine gland and the molecular pathways involved, with implications for understanding calcium homeostasis during development.