Award
National Institute of Diabetes and Digestive and Kidney Diseases 4R01DK135089-02
Why do Down Syndrome patients have high risk of Hirschsprung disease?
Recipient
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH
Award Amount
$843,812.00
Ceiling
$843,812.00
Awarded
August 11, 2025
Identifier
4R01DK135089-02
Research project funded by the National Institute of Diabetes and Digestive and Kidney Diseases to study the genetic basis of Hirschsprung disease risk in Down Syndrome patients using human genetics and model systems.
Description
The project involves investigating the genetic mechanisms underlying the high risk of Hirschsprung disease in Down Syndrome patients. The research includes human genetics, functional genomics in engineered pluripotent stem cells, and mouse models. The award is managed by the NIH Office of the Director. The project is funded for fiscal year 2025, with a start date of September 15, 2022, and an end date of July 31, 2027.