Award
Arkansas Children's Research Institute 5P20GM121293-10
Intersection of Uremic Toxins and Biological Sex in Chronic Kidney Disease Progression
Recipient
Arkansas Children's Hospital Res Inst
Award Amount
$217,584.00
Ceiling
$217,584.00
Awarded
July 06, 2026
Identifier
5P20GM121293-10
Research project studying how uremic toxins and biological sex affect chronic kidney disease progression, using a murine model to explore hormonal and receptor mechanisms.
Description
This project aims to investigate sex-specific effects of uremic toxins on CKD progression, focusing on the role of sex hormones and aryl hydrocarbon receptor activation in a murine model of Alport syndrome. The study involves manipulating systemic uremic toxin levels, pharmacologic inhibition of Ahr, and assessing renal clearance differences between sexes.