Award
National Institute of General Medical Sciences 5R35GM155117-03
Neuronal regulation of tissue-resident macrophage maintenance and polarization
Recipient
Kansas State University
Award Amount
$375,394.00
Ceiling
$375,394.00
Awarded
April 24, 2026
Identifier
5R35GM155117-03
NIH awarded a grant to Kansas State University for research on how nociceptor sensory neurons regulate tissue-resident macrophages, aiming to understand their role in inflammation and tissue repair to develop therapeutics for inflammatory diseases.
Description
This NIH grant supports research on neuron-immune interactions, focusing on macrophage polarization and neuropeptide signaling in inflammatory diseases. The project investigates the role of nociceptors and their subsets in tissue-resident macrophage development and function during steady-state and inflammation, using neuronal manipulation strategies in mice and neuropeptide-deficient models.