Award
National Institute of General Medical Sciences 5P20GM152335-03
Insulin Misfolding Dynamics and Insulin Signaling Dysfunction
Recipient
MC LAUGHLIN RESEARCH INSTITUTE, GREAT FALLS, MT, USA
Award Amount
$317,633.00
Ceiling
$317,633.00
Awarded
April 21, 2026
Identifier
5P20GM152335-03
This award supports research on insulin protein misfolding and its impact on insulin signaling dysfunction in Type 2 diabetes, with a focus on rural health implications in Montana.
Description
The project aims to examine the structure of the insulin protein and its role in glucose metabolism dysfunction related to Type 2 diabetes mellitus (T2DM). It involves detecting misfolded insulin, studying insulin fibrillization under destabilizing conditions, and investigating insulin resistance and metabolic dysfunction in animal models. The research uses innovative methods like Real Time-Quaking Induced Conversion (RTQuIC) and focuses on rural health challenges, particularly in Montana.