Award
NIH Reporter #5R61CA278536-03
Profiling and perturbing the inheritance of drug-induced metabolic states in cancer with Inheritance-Seq
Recipient
National Cancer Institute (NCI), part of the National Institutes of Health (NIH)
Award Amount
$206,820.00
Ceiling
$206,820.00
Awarded
May 01, 2026
Identifier
5R61CA278536-03
Award for developing Inheritance-Seq to study drug-induced cellular state inheritance in cancer, aiming to improve understanding of drug resistance and therapeutic strategies.
Description
This project involves developing and implementing inheritance-Seq, a method combining CRISPR-based genetic lineage tracing and phenotyping with microscopy and in situ sequencing to study the inheritance of drug-induced cellular states in cancer cells. The goal is to understand mechanisms of drug resistance and heritability of cellular states to improve therapeutic regimens.