Award
National Cancer Institute 5R01CA268899-05
A novel strategy for transcriptional reprogramming of lymphoid leukemia cells
Recipient
Thomas Jefferson University
Award Amount
$540,022.00
Ceiling
$540,022.00
Awarded
December 18, 2025
Identifier
5R01CA268899-05
NIH awarded a research grant to Thomas Jefferson University for a project developing a novel transcriptional reprogramming strategy to treat lymphoid leukemia by overcoming chromatin barriers and inducing leukemic cell differentiation and death.
Description
This NIH research grant project aims to develop a widely applicable treatment strategy for transcriptional reprogramming and loss of cell viability for many types of lymphoid leukemic cells. The approach involves pharmacological inhibition of the H3K27me3 histone methyltransferases EZH1/EZH2 to create a de-condensed chromatin structure, followed by activation of endogenous inducible transcription factors to induce cell differentiation and apoptosis, potentially eliminating leukemic cells.