Award
National Cancer Institute 5R01CA281295-04
KRAS G12C: Kinetic and Redox Characterization of Covalent Inhibition
Recipient
University of North Carolina at Chapel Hill
Award Amount
$569,072.00
Ceiling
$569,072.00
Awarded
March 19, 2026
Identifier
5R01CA281295-04
NIH grant awarded to University of North Carolina at Chapel Hill for research on KRAS G12C covalent inhibitors, aiming to understand inhibitor kinetics, redox sensitivity, and resistance mechanisms in cancer treatment.
Description
This NIH grant supports research on covalent inhibitors targeting KRAS G12C, focusing on understanding mechanisms of action and resistance, including redox modifications. The project includes structural and kinetic analysis of KRASG12C inhibitor engagement, investigation of redox modifications affecting inhibitor efficacy, development of models for resistance mechanisms, and evaluation of tumor redox properties and inhibitor response.