Award
National Institute of Allergy and Infectious Diseases 1R21AI193709-01
Role of HMGB1 in an experimental model of Bacterial ligand induced Vasculitis
Recipient
Cedars-Sinai Medical Center, Los Angeles, CA, United States
Award Amount
$459,250.00
Ceiling
$459,250.00
Awarded
June 20, 2025
Identifier
1R21AI193709-01
A research project funded by NIAID to study the role of HMGB1 in Kawasaki Disease vasculitis using a bacterial ligand-induced mouse model, aiming to develop novel therapies by blocking HMGB1.
Description
This project investigates the role and cellular source of HMGB1 in a murine model of Kawasaki Disease vasculitis induced by bacterial ligand Lactobacillus casei cell wall extract (LCWE). The study aims to determine the contribution of HMGB1 to disease pathogenesis and evaluate the therapeutic potential of blocking HMGB1 activity.