Award
National Heart, Lung, and Blood Institute 5R01HL167877-04
Modulating Fibrinolysis Dynamics by Leveraging Multivalent Avidity to Control Enzyme Activity
Recipient
Indiana University Indianapolis
Award Amount
$463,113.00
Ceiling
$463,113.00
Awarded
July 06, 2026
Identifier
5R01HL167877-04
The award funds research to develop safer direct fibrinolytic therapies by studying multivalent enzyme inhibition to improve blood clot digestion and reduce bleeding risks.
Description
This project aims to determine how homo- and hetero-multivalent inhibitors impact inhibition of plasmin and its interactions with regulatory proteins in vitro, evaluate the impact of reversible multivalent enzyme inhibition on clot digestion efficiency of standardized ex-vivo blood clots under shear, and examine the impact of multivalent inhibitor delivered plasmin on clot targeting and digestion in vivo. The goal is to develop a safer direct fibrinolytic therapeutic for conditions such as ischemic stroke, myocardial infarction, limb ischemia, PE, DVT, and occluded vascular catheters.